What is acyclovir
Decreased activity, lacrimation, closed eyelids, red-brown or brown material around the what eyes, nose and mouth, ataxia, prostration, body what tremors, urine stains around the what abdomen or genital area, scabbed or necrotic areas and alopecia were what observed in rats treated at 28 and 71 days of what age. Lifetime Oral Carcinogenicity Study in Mice There were acyclovir no signs of acyclovir toxicosis in Charles River CD-1 (ICR) mice (115 mice/sex/dose group) given acyclovir acyclovir by oral acyclovir gavage at 50, 150 and 450 mg/kg/day in a what lifetime oral carcinogenicity study. Hematology and clinical chemistry measurements were made on an additional 8 male and 8 female mice per group (dosed in the same manner) after the first and fourth weeks of dosing and during the 3rd what postdose week. Inconclusive results with no apparent dose-related response were obtained when acyclovir mutagenicity was what studied at each of 3 loci (aprt, hgprt and Ouabain-resistance) in Chinese hamster ovary (CHO) cells, both in the presence acyclovir and absence of exogenous acyclovir metabolic activation. Jama 1988; 260(19 2879-2882. Testicular atrophy was limited to acyclovir high-dose rats given 80 mg/kg/day for 6 acyclovir uses acyclovir months. Double-blind placebo-controlled trial of oral acyclovir in first-episode genital herpes what simplex virus infection. Sexually Transmitted Diseases Slideshow acyclovir Pictures Image Gallery: Picture of Genital Warts (HPV) Take the Genital Herpes Quiz What happens if I miss a dose (Sitavig, Zovirax)? Herpes simplex and varicella-zoster specified thymidine kinase acyclovir ointment transform acyclovir to its monophosphate which is then transformed by a number of cellular enzymes to acyclovir diphosphate and acyclovir triphosphate. The acyclovir effect of acyclovir on human cells was measured. It should be emphasized that the alterations in the nails appeared to be related to the transient toxicosis induced by dose levels of 50 and 150 mg/kg/day tested during the first two weeks of the study and. Rats in the high-dose group partially compensated by gaining significantly more body weight than the controls during the postdose recovery acyclovir period. Inhibition of the virus reduces the period of viral shedding, limits the degree of spread and level of pathology, and thereby facilitates healing. Standardized methods of virus sensitivity testing are required to allow more precise correlations between in vitro virus sensitivity and clinical response to acyclovir therapy. There were no drug-induced gross or microscopic lesions and there acyclovir was no evidence that acyclovir affected survival. Pathogenicity of acyclovir-resistant herpes simplex virus type 1 from an immunodeficient child. Missed dose: If you miss a dose, take it acyclovir as what soon as you remember. Recurrent genital herpes and suppressive oral acyclovir therapy. Acyclovir what treatment of varicella in otherwise healthy children. Further, there was no evidence of a dominant lethal effect on Charles River CD-1 (ICR) male and female mice treated orally at dose levels of 50, 150 and 450 mg/kg/day as summarized for the Two Generation Reproduction/ Fertility acyclovir Study. J Oral Maxillofac Surg 1987; 45(8 723-728. The latent state of the genome of any of the human herpesviruses is not known to be sensitive to acyclovir. The test compound was mutagenic what at the TK locus at high what concentrations (400 -2,400 g/mL). Comparative efficacy of antiherpes drugs in different cell lines. Sprague-Dawley female rats by subcutaneous injection during the period of organogenesis (day 6 through day 15 of gestation) at dose levels.0,.0,.5 and.0 mg/kg body weight twice daily. Can you spell these 10 commonly misspelled words? Mertz GJ, Jones CC, Mills J, what Fife KH, Lemon SM, Stapleton JT. Groups of 25 male and 25 female rats were administered intraperitoneal doses of acyclovir at 0, 5, 20 or 80 mg/kg/day for 6 months. A concentration.2 -.5 g/mL (50-100 M) inhibits the division of fibroblasts to a variable extent, depending on the experimental design and the confluency of the monolayer. Biron KK, Elion. Naib ZM, Nahmias AJ, Josey WE, Zaki. Thus, dose levels up to 60 mg/kg/day were well tolerated for one year. The dams were not treated. Developmental Toxicity Studies Neonatal Rats - Subchronic Study Acyclovir dissolved.4 sterile saline was given by subcutaneous injection to Charles River CD (Sprague-Dawley) neonatal rats for 19 consecutive days, beginning on the 3rd post-partum day. Straus SE, Seidlin M, Takiff H, Jacobs D, Bowen D, Smith. Do not use it later for another infection unless your doctor directs you to. Brand Names: Sitavig, Zovirax, medically reviewed on Feb 17, 2017, what is acyclovir? Common side effects may include: This is not a complete acyclovir 400 mg list of side effects and others may occur. Ann Intern Med 1990; 112(6 416-422. J Infect Dis 1982; 146(5 what 673-682. At what higher concentrations, 250 and 500 g/mL for 48 hours exposure, acyclovir caused a significant what increase what in the incidence of chromosome breakage. Nor were there meaningful alterations in values for the organs weighed at necropsy. Virology The quantitative relationship acyclovir between the in vitro susceptibility of herpes simplex virus (HSV) and varicella-zoster viruses (VZV) to acyclovir and the clinical response to therapy has not been what established in man, and virus sensitivity testing has not been what standardized. This document does not contain all possible drug interactions. The ID50 against VZV ranges from.17-1.53 g/mL (yield reduction, human foreskin fibroblasts).85-3.98 g/mL (foci reduction, human embryo fibroblasts HEF). Adults greater than 50 years of age showed greater benefit. There were 12 litters (each consisting of 5 male and 5 female neonates nursing the natural dam) at each dose level. Four daily doses of 100 mg/kg/day had no significant effect on Jerne hemolysin plaques or circulating antibody on day 7 after antigenic stimulation. Take your medicine as directed to best control your infection. You may eat and drink normally while the buccal tablet is in place. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Tell your doctor right away if any of these unlikely but what serious side effects occur: dizziness, drowsiness, signs of kidney problems (such as a change in the amount of urine, unusual back/side pain mental/mood changes (such as agitation, what confusion, hallucinations shaky/unsteady movement, trouble speaking. Corresponding mean values for the high-dose females were.81,.85 and.0 g/mL (43.60,.0 and.79 M). Subchronic Oral Toxicity Study Mice Four groups each consisting of 28 male and 28 female Charles River CD-1 (ICR) mice were orally dosed by stomach tube for 33 what days with suspensions of acyclovir. In a rat fertility study where groups of 20 male and 20 female rats were given 0,.5,.0 and.0 mg/kg/day by subcutaneous injection, acyclovir was shown what not to have an effect on mating or fertility. The ID50 against HSV-2 ranges from.01.9 g/mL (plaque reduction in Vero and GMK cells, respectively). Virus resistance in clinical practice. J Infect Dis 1983; 148(5 868-875. Distribution, plasma protein binding acyclovir is relatively low (9 to 33) and drug interactions involving binding site displacement are not anticipated. Further information Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use acyclovir only for the indication prescribed. Acyclovir can harm your kidneys. Allow the tablet to dissolve in your mouth throughout the day. Treatment of recurrent genital herpes simplex infections with oral acyclovir. However, it is not a cure for these infections. Thus, acyclovir is distinctly different than cytosine arabinoside which was reported to produce prominent cerebellar and retinal dysplasia in neonatal rats. Dosage reduction may be required in geriatric patients with reduced renal function (see. Crumpacker CS, Schnipper LE, Marlowe SI, Kowalsky PN, Hershey BJ, Levin. Table 7 :LD50 in Rats Age When Treated LD50 (mg/kg body weight) Males Females acyclovir Days Days Days There was no apparent relationship between length of survival after treatment and age at which treatment was given. The viruses that cause these infections continue to live in the body even between outbreaks. Barry DW, Blum. Pahwa S, Biron K, Lim W, Swenson P, Kaplan MH, Sadick N. Seek immediate medical acyclovir attention if any of these rare but serious side effects occur: extreme tiredness, what slow/fast/irregular heartbeat, easy bruising/bleeding, new fever, bloody/dark urine, severe stomach / abdominal pain, yellowing eyes / skin, sudden vision changes, loss of consciousness, seizures. Tumour tissues were diagnosed as being either undifferentiated sarcomas or lymphosarcomas. In a separate study in 20 volunteers, it was shown that zovirax Suspension what is bioequivalent to zovirax Capsules. Treatment was begun within 72 hours of rash onset and was most effective if started within the first 48 hours. Acyclovir, at concentrations.5 and 125 g/mL for a 48-hour exposure, did not induce any chromosome aberrations in cultured human lymphocytes in the absence of exogenous metabolic activation. Do not chew or swallow a buccal tablet. There was very little effect on cytotoxicity or LIF production except at concentrations of 200 g/mL (890 M) where there has already been demonstrated to be a direct cytotoxic effect. For 5 consecutive days, did not produce a dominant lethal effect in male BKA (cplp) mice. There were 9 male and 9 female dogs in each test group. A study in a tertiary care center. Take the missed acyclovir dose as soon as you remember. Am J Obstet Gynecol 1988; 158(3 Pt 1 586-588. If there was a transient effect on the corial epithelium (possibly related to direct effects or secondary to drug-induced illness during the first two weeks of the study) later loss of the nail could be a sequella. In 15 female rabbits treated intravenously with 50 mg/kg/day acyclovir on days 6 to 18 of gestation, there was no effect on either implantation efficiency or litter size. Acyclovir-resistant herpes simplex virus infection due to altered DNA polymerase. Do not use medications containing valacyclovir while using acyclovir. If you have genital herpes, it is very important to prevent herpes lesions during pregnancy. Copyright Cerner Multum, Inc. Chronic herpetic infection in an immunocompromised patient: report of a case. Efficacy and diminishing need during successive years of treatment. Jama 1988; 260(15 2227-2230. Christophers J, Sutton. Mutagenicity And Other Short-Term Studies Acyclovir has been tested for mutagenic potential in a number of in vitro and in vivo systems:November 10, 2014 Page 27 of 38 Microbial Acyclovir was tested for mutagenic activity in the Ames Salmonella plate. At a maximum tolerated intravenous dose of 50 mg/kg/day in rabbits there were no drug-related reproductive effects. Acyclovir, at a concentration of 50 g/mL (222 M) for a 72-hour exposure, has been shown to cause a statistically significant increase in the incidence of morphologically-transformed foci resulting from treating balb/C-3T3 cells in vitro in the absence of exogenous metabolic activation. Some histologic evidence of recovery of sperm production was evident 30 days postdose, but this was insufficient time to demonstrate full reversibility.
Acyclovir 800 mg
Acyclovir is an acyclovir antiviral drug. To make acyclovir sure acyclovir is safe for you, tell your acyclovir doctor if you have: kidney disease acyclovir 400 mg ; or a weak immune system (caused by disease or by using certain medicine). You may need to decide whether to stop breastfeeding or stop taking acyclovir this medication. These drugs are often used to treat similar conditions. To find out how this drug might interact with something else you're taking, talk to your doctor or pharmacist. Genital herpes is an acyclovir STD caused by two types of acyclovir viruses: herpes simplex type 1 and acyclovir herpes simplex type. This medication may also decrease your kidney function. Usual Pediatric Dose for Varicella-Zoster Immunocompetent acyclovir 400 mg host : 2 years or older acyclovir (40 kg or less 20 mg /kg orally 4 times a day for 5 days 2 years or older (over 40 kg 800 mg orally. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Your doctor will adjust your dose depending on how well your kidneys are working. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, acyclovir skill, knowledge and judgment of healthcare practitioners. CDC STD Treatment Guidelines and the Guidelines for the Prevention and Treatment of Opportunistic Infections Among HIV- Infected Adults and Adolescents may be consulted for additional guidance. This could result in dangerous side effects. Symptoms can include: trouble breathing swelling of your throat or tongue rash hives Call 911 or go to the nearest emergency room if you develop these symptoms. What to do if you miss a dose: Take your dose as soon as you remember. Do not chew or swallow a buccal tablet. Renal Dose Adjustments acyclovir Oral: For CrCl 0 to 10 mL/min/1.73 m2 : -If normal dose is 200 acyclovir mg orally every 4 hours 5 times a day: Reduce dose to 200 mg orally every 12 hours -If normal. Common side effects may include: This is not a complete list of side effects and others may occur. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that acyclovir uses outside of the United States are appropriate, unless specifically indicated otherwise. Acyclovir is am antiviral drug that belongs to a class of medications called "antivirals or "antiviral medications." Your doctor may prescribe this drug as a treatment to relieve symptoms of your infection. Don't take this drug again if you've ever had an allergic reaction. Dosages acyclovir Adult and Pediatric Dosage Forms and Strengths Injectable solution 50 mg /mL Oral suspension 200 mg /5mL Powder for injection 500 mg /vial 1 g/vial Dosage Considerations Should be Given as Follows: Genital Herpes Initial treatment. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Child dosage (ages 01 years) It hasn't been confirmed that acyclovir is safe and effective for children younger than acyclovir 2 years. This increases your risk of sunburn. Use: For the acute treatment of herpes zoster (shingles). For neonatal HSV with CNS involvement, confirm virus is absent from cerebrospinal fluid prior to stopping therapy; CSF HSV DNA PCR should be performed on days 19 and 21 and repeated as needed. Be sure to tell your doctor about all medications, vitamins, or herbs you're taking. CDC STD treatment Guidelines may be consulted for additional guidance. Not every pharmacy stocks this drug.
Your doctor may need to change the doses of your medications or monitor you carefully for side effects. However, get medical acyclovir help right away if you notice any ointment symptoms of a serious allergic reaction, including: rash, itching /swelling (especially of the face/tongue/throat severe dizziness, trouble breathing.This is not a complete list of possible side effects. Sometimes doctors prescribe acyclovir to treat herpes infections in acyclovir people with. If you think there has been an overdose, call your poison control center or get medical care right away. Do not have any kind of sex without using a latex or polyurethane condom. Storage, store at room temperature away from moisture. Try not to touch the cold sore. Precautions: Before using acyclovir, tell acyclovir your doctor or pharmacist if you are allergic to it; acyclovir or to valacyclovir ; or if you have any other allergies. Use topical acyclovir acyclovir exactly as directed. Therefore, systemic absorption of acyclovir after topical application is minimal. Acyclovir acyclovir cream should only be applied to skin where a cold sore has formed acyclovir or seems likely to form. Systemic exposure following topical administration is minimal. If you're taking acyclovir for genital herpes, it can reduce the severity or prevent recurrences of a herpes outbreak. Your symptoms should improve during your treatment with topical acyclovir. NDC store at 15 to 25C (59 acyclovir to 77F) ointment in ointment a dry place. Pregnancy: Teratogenic Effects Pregnancy Category. What do I need to tell my doctor before I take Acyclovir Ointment? Acyclovir does not cure cold sores or genital herpes, does not prevent outbreaks of these conditions, and does not stop the spread of these conditions to other people. Other reported clinical experience has not identified differences in acyclovir responses between the elderly and younger patients. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. This acyclovir ointment is accomplished in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. This includes your doctors, nurses, pharmacists, and dentists. Make sure to dry well. In studies of recurrent genital herpes and of herpes labialis in nonimmunocompromised patients, there was no evidence of clinical benefit; there was some decrease in duration of viral shedding. Avoid close physical contact with others (such as kissing) during an outbreak acyclovir until the cold sores have completely healed. Consult your pharmacist or local waste disposal formation last revised July 2016. HOW TO USE: Apply this medication to skin only. In this uncontrolled study, acyclovir was detected in the blood of 9 patients and in the urine of all patients tested. Other antiviral medications taken by mouth may be more effective in treating these conditions. The cream contains the unique antiviral agent Aciclovir which prevents the cold sore virus from replicating. Canada residents can call a provincial poison control center.